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The Gasser Lab
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We are studying the mechanisms by which stress hormones alter the structure and function of cells in the brain, with the goal of understanding how these actions contribute both to successful adaptation to stress, and to pathological conditions including depression, post-traumatic stress disorder, and drug abuse.
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People
[/et_pb_text][/et_pb_column][/et_pb_row][/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” _builder_version=”4.6.1″ _module_preset=”default” background_color=”rgba(0,0,0,0.75)”][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_team_member name=”Dr. Paul Gasser” position=”Associate Professor, Marquette University” image_url=”http://gasserlab.us/wp-content/uploads/2018/01/Paul-Gasser400x600.jpg” admin_label=”Paul Gasser Person” _builder_version=”4.6.1″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” background_layout=”dark” z_index_tablet=”500″ header_text_shadow_horizontal_length_tablet=”0px” header_text_shadow_vertical_length_tablet=”0px” header_text_shadow_blur_strength_tablet=”1px” body_text_shadow_horizontal_length_tablet=”0px” body_text_shadow_vertical_length_tablet=”0px” body_text_shadow_blur_strength_tablet=”1px” position_text_shadow_horizontal_length_tablet=”0px” position_text_shadow_vertical_length_tablet=”0px” position_text_shadow_blur_strength_tablet=”1px” body_link_text_shadow_horizontal_length_tablet=”0px” body_link_text_shadow_vertical_length_tablet=”0px” body_link_text_shadow_blur_strength_tablet=”1px” body_ul_text_shadow_horizontal_length_tablet=”0px” body_ul_text_shadow_vertical_length_tablet=”0px” body_ul_text_shadow_blur_strength_tablet=”1px” body_ol_text_shadow_horizontal_length_tablet=”0px” body_ol_text_shadow_vertical_length_tablet=”0px” body_ol_text_shadow_blur_strength_tablet=”1px” body_quote_text_shadow_horizontal_length_tablet=”0px” body_quote_text_shadow_vertical_length_tablet=”0px” body_quote_text_shadow_blur_strength_tablet=”1px” box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px” box_shadow_horizontal_image_tablet=”0px” box_shadow_vertical_image_tablet=”0px” box_shadow_blur_image_tablet=”40px” box_shadow_spread_image_tablet=”0px” text_shadow_horizontal_length_tablet=”0px” text_shadow_vertical_length_tablet=”0px” text_shadow_blur_strength_tablet=”1px” use_border_color=”off”]
[/et_pb_team_member][/et_pb_column][et_pb_column type=”3_4″ specialty_columns=”3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_row_inner column_structure=”1_3,1_3,1_3″ _builder_version=”4.6.1″ _module_preset=”default”][et_pb_column_inner type=”1_3″ saved_specialty_column_type=”3_4″ _builder_version=”4.6.1″ _module_preset=”default”][et_pb_team_member name=”Kelsey Benton” position=”PhD student” admin_label=”Kelsey Benton” _builder_version=”4.6.1″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” background_layout=”dark” use_border_color=”off”][/et_pb_team_member][et_pb_team_member name=”Saema Khursheed” position=”Junior, Biomedical Sciences” admin_label=”Dan Wheeler” _builder_version=”3.25.2″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” background_layout=”dark” use_border_color=”off”][/et_pb_team_member][/et_pb_column_inner][et_pb_column_inner type=”1_3″ saved_specialty_column_type=”3_4″ _builder_version=”4.6.1″ _module_preset=”default”][et_pb_team_member name=”Abby Doohan” position=”Senior, Biomedical Sciences” admin_label=”Dan Wheeler” _builder_version=”3.25.2″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” background_layout=”dark” use_border_color=”off”][/et_pb_team_member][et_pb_team_member name=”Brad Roy” position=”Senior, Biomedical Sciences” admin_label=”Kelsey Benton” _builder_version=”3.25.2″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” background_layout=”dark” z_index_tablet=”500″ header_text_shadow_horizontal_length_tablet=”0px” header_text_shadow_vertical_length_tablet=”0px” header_text_shadow_blur_strength_tablet=”1px” body_text_shadow_horizontal_length_tablet=”0px” body_text_shadow_vertical_length_tablet=”0px” body_text_shadow_blur_strength_tablet=”1px” position_text_shadow_horizontal_length_tablet=”0px” position_text_shadow_vertical_length_tablet=”0px” position_text_shadow_blur_strength_tablet=”1px” body_link_text_shadow_horizontal_length_tablet=”0px” body_link_text_shadow_vertical_length_tablet=”0px” body_link_text_shadow_blur_strength_tablet=”1px” body_ul_text_shadow_horizontal_length_tablet=”0px” body_ul_text_shadow_vertical_length_tablet=”0px” body_ul_text_shadow_blur_strength_tablet=”1px” body_ol_text_shadow_horizontal_length_tablet=”0px” body_ol_text_shadow_vertical_length_tablet=”0px” body_ol_text_shadow_blur_strength_tablet=”1px” body_quote_text_shadow_horizontal_length_tablet=”0px” body_quote_text_shadow_vertical_length_tablet=”0px” body_quote_text_shadow_blur_strength_tablet=”1px” box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px” box_shadow_horizontal_image_tablet=”0px” box_shadow_vertical_image_tablet=”0px” box_shadow_blur_image_tablet=”40px” box_shadow_spread_image_tablet=”0px” use_border_color=”off”][/et_pb_team_member][/et_pb_column_inner][et_pb_column_inner type=”1_3″ saved_specialty_column_type=”3_4″ _builder_version=”4.6.1″ _module_preset=”default”][et_pb_team_member name=”Matt Merwin” position=”Senior, Biomedical Sciences” admin_label=”Rachel Knorr” _builder_version=”3.25.2″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” background_layout=”dark” use_border_color=”off”][/et_pb_team_member][/et_pb_column_inner][/et_pb_row_inner][/et_pb_column][/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” _builder_version=”4.8.1″ _module_preset=”default” background_image=”https://gasserlab.us/wp-content/uploads/2021/01/x-DC-11-Jul-2016-ms-astrocytes-20x-B1-image-3-web.jpg” custom_padding=”20px||20px||true|false” custom_padding_tablet=”20px||20px||true|false” custom_padding_phone=”” hover_enabled=”0″ title_text=”x-DC-11-Jul-2016-ms-astrocytes-20x-B1-image-3-web” sticky_enabled=”0″][et_pb_row custom_padding_last_edited=”on|phone” _builder_version=”4.6.1″ _module_preset=”default” custom_padding=”30px||30px||true|false” custom_padding_tablet=”20px||20px||true|false” custom_padding_phone=”10px||10px||true|false”][et_pb_column type=”4_4″ _builder_version=”4.6.1″ _module_preset=”default”][et_pb_text _builder_version=”4.6.1″ _module_preset=”default” header_font=”|700|||||||” header_text_align=”left” header_text_color=”#ffffff” header_font_size=”60px” header_2_font=”|700|||||||” header_2_font_size=”50px” background_layout=”dark” header_font_size_tablet=”40px” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” header_2_font_size_tablet=”50px” header_2_font_size_phone=”40px” header_2_font_size_last_edited=”on|phone”]
Projects
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Our current research projects are focused on understanding interactions between corticosteroid hormones and monoamine neurotransmitters in the regulation of neuronal and glial function. Specifically, we are examining the role of organic cation transporter 3 (OCT3), a high capacity transporter for monoamines that is directly inhibited by corticosteroids, in regulating signaling processes initiated by dopamine and norepinephrine.
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Publications
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Google Scholar Profile
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Holleran KM, Rose JH, Fordahl SC, Benton KC, Rohr KE, Gasser PJ, Jones SR (2020). Organic cation transporter 3 and the dopamine transporter differentially regulate catecholamine uptake in the basolateral amygdala and nucleus accumbens. Eur J Neurosci. https://onlinelibrary.wiley.com/share/author/GECCHYEMCWQGKTXIYRPS?target=10.1111/ejn.14927
Gasser PJ (2018). Roles for the uptake2 transporter OCT3 in regulation of dopaminergic neurotransmission and behavior. Neurochem. Int. https://doi.org/10.1016/j.neuint.2018.07.008
Gasser PJ and Lowry CA (2018). Organic cation transporter 3: a cellular mechanism underlying rapid, non-genomic glucocorticoid regulation of monoaminergic neurotransmission, physiology, and behavior. Horm. Beh. https://doi.org/10.1016/j.yhbeh.2018.05.003
Gasser PJ and Daws LC (2017) Extending the Family: Roles for Uptake2 transporters in Regulation of Monoaminergic Signaling. J Chem Neuroanat. 83-84:107-108.
Wheeler DS, Ebben AL, Kurtoglu B, Lovell ME, Bohn AT, Jasek IA, Baker DA, Mantsch JR, Gasser PJ, Wheeler RA. (2017) Corticosterone regulates both naturally occurring and cocaine-induced dopamine signaling by selectively decreasing dopamine uptake. Eur. J. Neurosci. 46: 2638-2646.
Gasser PJ and Daws LC (2017) Extending the Family: Roles for Uptake2 transporters in Regulation of Monoaminergic Signaling. J Chem Neuroanat.
Gasser PJ, Hurley MM, Chan J, Pickel VM. (2016) Organic Cation Transporter 3 (OCT3) is targeted to intracellular and surface membranes in select glial and neuronal cells within the lateral amygdaloid complex of both rats and mice. Brain Structure and Function 222(4): 1913-1928.
McReynolds JR, Taylor A, Ambrosius T, Derricks O, Vranjkovic O, Nino B, Kurtoglu B, Baker DA, Wheeler RA, Gasser PJ, Mantsch JR. (2016) Corticosterone potentiation of cocaine-induced reinstatement of conditioned place preference in mice is mediated by blockade of the organic cation transporter 3. Neuropsychopharm. 42(3):757-765.
Kloehn I, Pillai SB, Officer L, Klement C, Gasser PJ, Evans JA. (2016) Sexual differentiation of circadian clock function in the adrenal gland. Endocrinology. 157(5): 1895-1904.
Mantsch JR and Gasser PJ (2015) Glucocorticoid involvement in drug abuse and addiction. In “Stress Neuroendocrinology” J Russell, ed. John Wiley & Sons, Chichester, UK
Vranjkovic O, Gasser PJ, Gerndt CH, Baker DA, Mantsch JR. (2014) Stress-induced cocaine seeking requires a beta-2 adrenergic receptor-regulated pathway from the ventral bed nucleus of the stria terminalis that regulates CRF actions in the ventral tegmental area. J. Neurosci. 34: 12504-12514.
Mantsch JR, Vranjkovic O, Twining RC, Gasser PJ, McReynolds JR, Blacktop JM. (2014) Neurobiological mechanisms that contribute to stress-related cocaine use. Neuropharmacology 76(B):383-394.
Graf EN, Wheeler RA, Baker DA, Ebben AL, Hill JE, McReynolds JR, Robble MA, Vranjkovic O, Wheeler DS, Mantsch JR, Gasser PJ. (2013) Corticosterone acts in the nucleus accumbens to enhance dopamine signaling and promote cocaine use. J. Neurosci. 33: 11800-11810.
Hill JE and Gasser PJ. (2013). Organic cation transporter 3 is densely expressed in the intercalated cell groups of the amygdala: Anatomical evidence for a stress hormone-sensitive dopamine clearance system. J. Chem. Neuroanat. 52: 36-43.
Hill JE, Makky K, Shrestha L, Hillard CJ, Gasser PJ. (2011) Natural and synthetic corticosteroids inhibit uptake2-mediated transport in CNS neurons. Physiol Behav 104: 306-311.
Gasser PJ, Orchinik M, Raju I, Lowry CA (2009) Distribution of organic cation transporter 3, a corticosterone-sensitive monoamine transporter, in the rat brain. J Comp Neurol 512 (4): 529-555.
Gasser PJ, Lowry CA, Orchinik M (2009) Acute corticosteroid action in the brain: mechanisms and implications. In: “Hormones, Brain, and Behavior” 2nd edition, D. Pfaff, A. Arnold, A. Etgen, S. Fahrbach, R. Rubin, eds. Academic Press, San Diego.
Lowry CA, Evans AK, Gasser PJ, Hale MW, Staub DR, Shekhar A (2008) Topographic organization and chemoarchitecture of dorsal
raphe nucleus and the median raphe nucleus. In: “Serotonin and sleep: Molecular, Functional and Clinical Aspects”. Monti JM, Pandi-Perumal SR, Jacobs BL, Nutt DJ (Eds) Birkhauser Verlag AG, Basel, Switzerland.
Lowry CA, Hale MW, Evans AK, Heerkens J, Staub D, Gasser PJ, Shekhar A (2008) Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. In: “Stress, Neurotransmitters, and Hormones: Neuroendocrine and Genetic Mechanisms” R. Kvetnansky, G. Aguilera, D. Goldstein, D. Jezova, O. Krizanova, E. Sabban, K. Pacek, eds. Ann. NY Acad. Sci. 1148: 86-94.
Gasser PJ, Orchinik M (2007) Vasopressin-induced translocation and proteolysis of protein kinase Cα in an amphibian brain: modulation by corticosterone. Brain Res. 1134 (1):18-26.
Gasser PJ, Lowry CA, Orchinik M (2006) Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for
organic cation transporter 3 in stress-induced modulation of monoaminergic neurotransmission. J. Neurosci. 26 (34): 8758-8766.
Orchinik M, Matthews L, Gasser PJ (2000) Distinct specificity for corticosteroid binding sites in amphibian cytosol, neuronal membranes, and plasma. Gen. Comp. Endocrinol. 118: 284-301.
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